Ms. Rudoltz et al., MULTIPLE CAUSES OF CEREBROVASCULAR EVENTS IN CHILDREN WITH TUMORS OF THE PARASELLAR REGION, Journal of neuro-oncology, 37(3), 1998, pp. 251-261
Cerebrovascular arterial occlusion is a rare but devastating event cau
sing long-term morbidity in children with tumors in the parasellar reg
ion. While usually associated with radiation therapy, there are a vari
ety of host, tumor and treatment factors which predispose patients to
significant vasculopathy. Case reports of 5 patients from St. Jude Chi
ldren's Research Hospital with tumors in the parasellar region who pre
sented with or developed vascular occlusive disease are summarized. Mu
ltiple factors are identified in these cases which probably impacted o
n the development of cerebral arterial occlusion with or without moyam
oya syndrome. These include, but are not limited to, neurofibromatosis
, tumor encasement of major cerebral vessels, surgical alterations, an
d radiation therapy. The literature supports multiple, potentially int
eractive etiologies for the development of vascular events in these pa
tients, suggesting that their development is not simply a phenomenon r
elated to radiation therapy.