An unusual case of cerebellar neurocytoma with rhabdomyomatous differe
ntiation in a 6-year-old boy is reported. Immunocytochemical and ultra
structural features of the tumour were studied. Abortive synapse forma
tion, the presence of clear vesicles and synaptophysin immunoreactivit
y of the tumour cells indicated its intermediate neuronal differentiat
ion, while the presence of myoblasts and myotubes and immunolabelling
by desmin confirmed the rhabdomyomatous differentiation, In addition,
the mesenchymal cells variably expressed neurofilament protein and gli
al fibrillary acidic protein, suggesting inductive interaction between
the neuroectodermal and ectomesenchymal elements and persistence of t
he pleuripotential nature of the cells along the rhombic area of the b
rain stem.