PENTAVALENT TECHNETIUM-99M-DIMERCAPTOSUCCINIC ACID SCINTIGRAPHY IN RENAL OSTEODYSTROPHY

Pentavalent Tc-99m-dimercaptosuccinic acid (DMSA) scintigraphy and Tc- 99m-hydroxymethylene diphosphonate (HMDP) bone scan were performed in one patient with renal osteodystrophy (ROD) before and after vitamin D -3 pulse therapy, The bone scan showed diffusely increased tracer upta ke in the whole skeleton, and no change of tracer distribution was not ed before or after vitamin D-3 pulse therapy, However, (TC)-T-99m(V)-D MSA scintigraphy revealed diffusely increased tracer uptake in the who le skeleton before therapy, and markedly decreased tracer uptake in th e bones was seen at 5 mo after therapy, Increased uptake of Tc-99m(V)- DMSA was observed at 7 mo after therapy, which reflected the laborator y findings, Technetium-99m-M-DMSA scintigraphy appeared to be more sen sitive than the conventional Tc-99m-HMDP bone scan in assessing the ch aracteristics and therapeutic effect of bone disease in ROD.