S. Conde et al., LIPASE-CATALYZED AMIDATION OF DIETHYL GLUTAMATE DERIVATIVES - PECULIARITIES OF ETHYL S-PYROGLUTAMATE AND R-PYROGLUTAMATE, Biotechnology letters, 20(3), 1998, pp. 261-263
Candida antarctica lipase mediated amidation of both ethyl S- and R-py
roglutamate at 60 degrees C takes place in less than 5 minutes. Kineti
c differences, S-enantiomer rate higher than that of R, appeared when
the reaction was performed at 45 degrees C.