PRODUCTION OF ARTEMISININ BY HAIRY ROOT CULTURES OF ARTEMISIA-ANNUA LIN BIOREACTOR

Hairy root cultures of Artemisia annua L were cultivated in four diffe rent culture systems: a flask, a bubble column, a modified bubble colu mn and a modified inner-loop airlift bioreactor. The artemisinin conte nts of hairy root cultures in the bubble column and the modified inner -loop airlift bioreactor were higher than that in the modified bubble column. The growth rate and hairy root distribution in the modified in ner-loop airlift bioreactor were better than those in other bioreactor s, and dry weight and artemisinin production reached to 26.8 g/L and 5 36 mg/L after 20 days.