A VERSION OF HODGKIN-HUXLEY MODEL WITH RE DUCED NUMBER OF PARAMETERS

Citation
Ov. Tsvetkov et al., A VERSION OF HODGKIN-HUXLEY MODEL WITH RE DUCED NUMBER OF PARAMETERS, Biofizika, 43(1), 1998, pp. 109-114
Citations number
9
Categorie Soggetti
Biophysics
Journal title
ISSN journal
00063029
Volume
43
Issue
1
Year of publication
1998
Pages
109 - 114
Database
ISI
SICI code
0006-3029(1998)43:1<109:AVOHMW>2.0.ZU;2-A
Abstract
The time constants of variations in sodium and potassium conductances of neural cell membrane have been investigated as a function of transm embrane potential. It is shown that the dependences can be described b y the model of selforganization and selfregulation in open dynamic sys tems reported early. This approach has two advantages over the empiric al formulae by Hodgkin and Huxley: 1) the number of parameters to be d efined is substantially reduced, which simplifies modeling of real cel ls, and 2) the model involves a particular mechanism by which the tran smembrane potential regulates the time constants of variations in memb rane conductance, which can promote further development of theoretical conceptions of the action potential generation process.