In clinical practice much more often one meets a necessity of repeated
administration of fluorocarbon blood substitutes. The F-19(-)-NMR-spe
ctroscopy has been used to study the kinetics of the blood and tissue
fluorocarbon concentration after repeated administration of PFC emulsi
on. Analysis of the data suggests that redistribution of PFCs between
organs and blood after their repeated administration is under control
of Ostwald ripening depending on PFC physicochemical properties (water
and lipid solubility), emulsion particle diameter etc and does not co
nnect with activity of reticuloendothelial system.