THE MECHANISM OF ACCUMULATION AND ELIMINA TION OF PERFLUOROCARBONS ATREPEATED ADMINISTRATION

Authors
SKLIFAS AN SHEKHTMAN DG OBRAZTSOV VV VOROBJEV SI TEMNOVA IV
Citation
An. Sklifas et al., THE MECHANISM OF ACCUMULATION AND ELIMINA TION OF PERFLUOROCARBONS ATREPEATED ADMINISTRATION, Biofizika, 43(1), 1998, pp. 171-176
Citations number
12
Categorie Soggetti
Biophysics
Journal title
Biofizika → ACNP
ISSN journal
00063029
Volume
43
Issue
1
Year of publication
1998
Pages
171 - 176
Database
ISI
SICI code
0006-3029(1998)43:1<171:TMOAAE>2.0.ZU;2-I
Abstract
In clinical practice much more often one meets a necessity of repeated administration of fluorocarbon blood substitutes. The F-19(-)-NMR-spe ctroscopy has been used to study the kinetics of the blood and tissue fluorocarbon concentration after repeated administration of PFC emulsi on. Analysis of the data suggests that redistribution of PFCs between organs and blood after their repeated administration is under control of Ostwald ripening depending on PFC physicochemical properties (water and lipid solubility), emulsion particle diameter etc and does not co nnect with activity of reticuloendothelial system.