The application of reference materials (RMs) for quality control in an
alytical chemistry within long-term environmental monitoring and banki
ng programs is described. The profitable use of different levels of RM
s, in particular the introduction of problem-designed internal control
materials and internal reference materials at the German Environmenta
l Specimen Bank is demonstrated. Moreover, further demands from biosph
ere-oriented programs for future developments of certified reference m
aterials (CRMs) are discussed.