CONSTANT INFUSION RATES OF LIPID EMULSIONS TO STABILIZE PLASMA TRIGLYCERIDE CONCENTRATIONS - MEDIUM-CHAIN TRIGLYCERIDE LONG-CHAIN TRIGLYCERIDE EMULSIONS (MCT LCT) VERSUS LCT/

As medium-chain triglyceride emulsions (MCT) are more rapidly hydrolyz ed than long-chain triglyceride emulsions (LCT), MCT/LCT tends to be i nfused faster than LCT, The purpose of the present study was to determ ine the most appropriate infusion rate for MCT/LCT to stabilize plasma concentrations of triglyceride (TG), being equivalent to the optimal infusion rate of the emulsion. A TG clamp was set up by raising the me an +/- SD concentrations of TG in plasma, being 1.08 +/- 0.18 Delta mm ol l(-1) for LCT, and 1.65 +/- 0.31 Delta mmol l(-1) for MCT/LCT after a 50-min priming infusion of each emulsion, Thereafter, the infusion rate of lipid was controlled every 10 min to maintain a steady concent ration of TG for a period of 150 min, A constant infusion of glucose a t 0.32 g/kg body weight (EW) per h was administered for the test perio d, The weight-based rate of the infusion to maintain a steady state of plasma TG concentrations did not differ between MCT/LCT and LCT, bein g 0.125 +/- 0.013 vs 0.117 +/- 0.021 g/kg BW per h, while the molar-ba sed infusion rate was 0.203 +/- 0.021 mmol/kg BW per h for MCT/LCT and 0.132 +/- 0.023 mmol/kg BW per h for LCT (P < 0.05). These results su ggest that although 54% more molar MCT/LCT-TG can be hydrolyzed during a constant infusion, MCT/LCT should not be infused at a rate faster t han 0.1 g/kg BW per h under a steady state.