PREOPERATIVE GNRH ANALOG IN HYSTEROSCOPIC METROPLASTY

Objective, To evaluate the effectiveness of Gonadotropin-Releasing Hor mone analogue when administered preoperatively in hysteroscopic metrop lasty. Design, Prospective, comparative study. Patients and main outco me measures. Sixty patients undergoing hysteroscopic metroplasty for s eptate uterus who were randomly allocated to pretreatment with two inj ections monthly of Gonadotropin-Releasing Hormone analogue or to no pr etreatment, To assess the outcome of surgery three parameters were use d: operative time (minutes), fluid adsorption (mi) and intraoperative bleeding. Results. No significant differences in the operating time (2 1.9 vs 22.9 min), fluid adsorption (395 mi, range 200-550 vs 515 mi, r ange 250-650), intraoperative bleeding and failure rate were found bet ween pretreated patients and controls. Conclusions. Preoperative treat ment with Gonadotropin-Releasing Hormone analogue showed no advantage in hysteroscopic treatment of mullerian defects, but only an improveme nt, not statistically significant, in term of reduced operative time a nd fluid adsorption.