Review of the role of blood rheology in regulating blood pressure disc
loses that macromolecular binding to the erythrocyte membrane is a sig
nificant factor. Evidence is summarized supporting the thesis that. bl
ood viscosity is a prime regulator of blood pressure. Macromolecules m
ay bind io erythrocytes and other macromolecules forming structures th
at increase blood viscosity when the blood stream flow rate is decreas
ed. Review of the nature and extent of RBC membrane binding and a mode
l for relating these bonds to blood pressure are presented.