RELEASE OF PEPTIDE YY AND INHIBITION OF GASTRIC-ACID SECRETION BY LONG-CHAIN AND MEDIUM-CHAIN TRIGLYCERIDES BUT NOT BY SUCROSE POLYESTER INMEN

Methods In the present study, we have investigated the effects of intr aduodenal perfusion of long-chain and medium-chain triglycerides and o f sucrose polyester on the release of peptide YY in healthy men. Resul ts Perfusion of medium-chain triglycerides (180 mmol fatty acids) incr eased the plasma concentration of peptide YY from 7.9 pmol L-1 (SEM 0. 2, n = 8) to 10.7 pmol L-1 (SEM 0.5, n = 8), whereas perfusion of long -chain triglycerides (180 mmol fatty acids) had a significantly greate r effect, increasing peptide YY concentration from 8.6 pmol L-1 (SEM 0 .2, n = 8) to 18.9 pmol L-1 (SEM 2.4, n = 8, P < 0.008). A smaller qua ntity of long-chain triglycerides (90 mmol fatty acids) increased plas ma concentration of peptide YY from 7.4 pmol L-1 (SEM 0.4, n = 8) to 1 3.3 pmol L-1(SEM 1.5, n = 8), whereas sucrose polyester (90 mmol fatty acids) did not change peptide YY concentration. In a previous study, we investigated gastrin-stimulated gastric acid output in response to these treatments. The correlation between increases in peptide YY in r esponse to all treatments and the decrease in acid output was r = 0.72 (n = 48, P < 0.0001_). These results show that both long-chain and me dium-chain triglycerides, but not sucrose polyester, stimulate the rel ease of peptide YY. Conclusion We speculate that peptide YY may play a n important role in the inhibition of gastrin-stimulated gastric acid secretion by long-chain and medium-chain triglycerides.