ENHANCING EFFECTS OF BETA-ENDORPHIN ON GLUTAMATE NEUROTOXICITY

Citation
L. Zhu et al., ENHANCING EFFECTS OF BETA-ENDORPHIN ON GLUTAMATE NEUROTOXICITY, Zhongguo yaoli xuebao, 19(2), 1998, pp. 108-111
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
02539756
Volume
19
Issue
2
Year of publication
1998
Pages
108 - 111
Database
ISI
SICI code
0253-9756(1998)19:2<108:EEOBOG>2.0.ZU;2-H
Abstract
AIM: To study the effects of beta-endorphin (beta-End) on monosodium g lutamate (MSG)-induced neurotoxicity (GNT). METHODS: Image analysis of neuronal areas and determination of mitochondrial membrane protein-bo und Ca2+ and intracellular free Ca2+ ([Ca2+](i)) were used, RESULTS: b eta-End aggravated MSG-induced neuronal injury in arcuate nucleus of h ypothalamus in a dose-dependent manner in the range from 0.5 to 5.0 mg . kg(-1). MSG-induced increase in mitochondrial membrane protein-boun d Ca2+ was enhanced when treated with beta-End 2 g . L-1. MSG-induced elevation in [Ca2+](i) in single neuron was also augmented from 320 +/ - 84 to 589 +/- 78 nmol . L-1 by the treatment with beta-End 2 g . L-1 . CONCLUSION: beta-End enhanced GNT via aggravating the disruption of intracellular Ca2+ homeostasis induced by MSG.