A THERAPEUTIC TRIAL OF RADIATION-THERAPY WITH VINCRISTINE, ETOPOSIDE,AND PROCARBAZINE (VVP) IN HIGH-GRADE INTRACRANIAL GLIOMAS - AN EASTERN-COOPERATIVE-ONCOLOGY-GROUP STUDY (E2392)

Authors
HELLMAN R NEUBERG DS WAGNER H GUNNET M ROBINS HI KARP D FLYNN P ADAMS G
Citation
R. Hellman et al., A THERAPEUTIC TRIAL OF RADIATION-THERAPY WITH VINCRISTINE, ETOPOSIDE,AND PROCARBAZINE (VVP) IN HIGH-GRADE INTRACRANIAL GLIOMAS - AN EASTERN-COOPERATIVE-ONCOLOGY-GROUP STUDY (E2392), Journal of neuro-oncology, 37(1), 1998, pp. 55-62
Citations number
16
Categorie Soggetti
Clinical Neurology",Oncology
Journal title
Journal of neuro-oncology → ACNP
ISSN journal
0167594X
Volume
37
Issue
1
Year of publication
1998
Pages
55 - 62
Database
ISI
SICI code
0167-594X(1998)37:1<55:ATTORW>2.0.ZU;2-5
Abstract
This study is a combined modality Phase II therapeutic trial to determ ine the efficacy of the novel combination of VP-16, Vincristine and Pr ocarbazine in addition to postoperative radiation therapy in patients with high grade intracranial gliomas. Thirty three patients (median ag e 51 years) were entered (27 with glioblastoma multiforme, 6 with anap lastic astrocytoma). Toxicity was manageable with no lethal toxicities . Five of seven life threatening toxicities were hematologic. Median o verall survival was 14.2 months. These data suggest this regimen is ef fective treatment for patients with high grade gliomas.