A NEW CONVENIENT SYNTHESIS OF 5-ACYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2-THIONES ONES/

Authors
SHUTALEV AD KISHKO EA SIVOVA NV KUZNETSOV AY
Citation
Ad. Shutalev et al., A NEW CONVENIENT SYNTHESIS OF 5-ACYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2-THIONES ONES/, Molecules, 3(3), 1998, pp. 100-106
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Molecules → ACNP
ISSN journal
14203049
Volume
3
Issue
3
Year of publication
1998
Pages
100 - 106
Database
ISI
SICI code
1420-3049(1998)3:3<100:ANCSO5>2.0.ZU;2-B
Abstract
An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine- 2-thiones/ones is described. The synthesis is based on the reaction of readily available a-tosyl substituted thioureas or ureas with enolate s of beta-oxoesters or 1,3-dicarbonyl compounds followed by acid-catal yzed dehydration of the obtained -acyl-4-hydroxyhexahydropyrimidine-2- thiones/ones.