Oculosympathetic function was studied in 20 headache-free migraine pat
ients and in 20 controls. Pupillary investigation was performed under
basal conditions, and after instillation of tyramine (2%) and phenylep
hrine (1%) eyedrops. Each test was performed twice shortly after a spo
ntaneous attack and then repeated after 7 and 15 days. In the patients
, the normal mydriatic response induced by tyramine was significantly
(p<0.001) reduced and phenylephrine instillation caused a significant
(p<0.01) pupillary dilatation in both the assessments performed shortl
y after the attack. These abnormal responses were bilateral in all pat
ients and slightly anisocoric in some. They were significantly (p<0.00
1) more pronounced in the patients who had pain and pronounced vascula
r features. The reduced oculosympathetic response to ts?amine, as well
as the hypersensitivity to phenylephrine, was less evident 7 days aft
er the attack and absent after 15 days. A transient and bilateral post
-ganglionic oculosympathetic hypofunction, with adrenoceptor hypersens
itivity, was found to be temporally related to the migraine attack, re
gardless of the side or predominant side of pain.