SOLID-PHASE SYNTHESIS OF A BIASED MINI TETRAPEPTOID-LIBRARY FOR THE DISCOVERY OF MONODENTATE ITAM MIMICS AS ZAP-70 INHIBITORS

Authors
REVESZ L BONNE F MANNING U ZUBER JF
Citation
L. Revesz et al., SOLID-PHASE SYNTHESIS OF A BIASED MINI TETRAPEPTOID-LIBRARY FOR THE DISCOVERY OF MONODENTATE ITAM MIMICS AS ZAP-70 INHIBITORS, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 405-408
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
405 - 408
Database
ISI
SICI code
0960-894X(1998)8:5<405:SSOABM>2.0.ZU;2-Y
Abstract
The biased library was composed of a novel phosphotyrosine mimic fixed in the P1 position of a tetrapeptoid and combined with three lipophil ic N-substituents at the remaining positions giving a total of 27 sing le compounds. Screening for ZAP-70 antagonism identified 8 as a novel selective monodentate ZAP-70 antagonist and lead in the search for new immunosuppressive drugs. (C) 1998 Elsevier Science Ltd. All rights re served.