SOLID-PHASE SYNTHESIS OF N-CARBOXY ALKYL-CONTAINING PEPTIDES DERIVED FROM ENANTIOPURE ALPHA-KETO-BETA-AMINO-ACIDS

Authors
FERNANDEZGARCIA C PRAGER K MCKERVEY MA WALKER B WILLIAMS CH
Citation
C. Fernandezgarcia et al., SOLID-PHASE SYNTHESIS OF N-CARBOXY ALKYL-CONTAINING PEPTIDES DERIVED FROM ENANTIOPURE ALPHA-KETO-BETA-AMINO-ACIDS, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 433-436
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
433 - 436
Database
ISI
SICI code
0960-894X(1998)8:5<433:SSONAP>2.0.ZU;2-H
Abstract
alpha-Keto-beta-aminoacids 5a-c can be reductively aminated with the p eptide sequence H2N-Leu-Val-Phe-Phe on a solid support to afford N-car boxy alkyl peptides la-c. The N-carboxy alkyl lysine derivative 7 was subsequently extended from the N-terminus with glutamine and histidine residues. (C) 1998 Elsevier Science Ltd. All rights reserved.