ANTIMALARIAL ACTIVITIES OF ACYLATED BRUCEOLIDE DERIVATIVES

Authors
MURAKAMI N UMEZOME T MAHMUD T SUGIMOTO M KOBAYASHI M WATAYA Y KIM HS
Citation
N. Murakami et al., ANTIMALARIAL ACTIVITIES OF ACYLATED BRUCEOLIDE DERIVATIVES, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 459-462
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
459 - 462
Database
ISI
SICI code
0960-894X(1998)8:5<459:AAOABD>2.0.ZU;2-3
Abstract
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propion yl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a) , exhibited potent anti-malarial activities with high selective toxici ties. (C) 1998 Elsevier Science Ltd. All rights reserved.