STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF 1-SUBSTITUTED-4-METHYLBENZIMIDAZOLE NEUROPEPTIDE Y-1 RECEPTOR ANTAGONISTS

Authors
ZIMMERMAN DM CANTRELL BE SMITH ECR NIXON JA BRUNS RF GITTER B HIPSKIND PA ORNSTEIN PL ZARRINMAYEH H BRITTON TC SCHOBER DA GEHLERT DR
Citation
Dm. Zimmerman et al., STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF 1-SUBSTITUTED-4-METHYLBENZIMIDAZOLE NEUROPEPTIDE Y-1 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 473-476
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
473 - 476
Database
ISI
SICI code
0960-894X(1998)8:5<473:SOASO1>2.0.ZU;2-0
Abstract
The characterization of a novel series of NPY-I receptor antagonists d erived from the 4-methylbenzimidazole 4 is described. Appropriate subs titution on the piperidyl nitrogen of 4 led to systematic increases in Y-1 receptor affinity, to approximately 50-fold, and to the discovery of the importance of a second basic substituent. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.