NEW BRONCHODILATORS SELECTED BY MOLECULAR TOPOLOGY

Authors
RIOSSANTAMARINA I GARCIADOMENECH R GALVEZ J CORTIJO J SANTAMARIA P MORCILLO E
Citation
I. Riossantamarina et al., NEW BRONCHODILATORS SELECTED BY MOLECULAR TOPOLOGY, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 477-482
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
477 - 482
Database
ISI
SICI code
0960-894X(1998)8:5<477:NBSBMT>2.0.ZU;2-S
Abstract
Molecular topology has been applied to find new lead compounds with br onchodilator activity. Among the selected compounds stands out tetrazo l-5yl)-9H-thioxanthene-9-one-10,10-dioxide, anthrarobin, 9-oxo-9H-thio xantene-3-carboxylic-10, 10-dioxide acid, acenocoumarol and griseofulv in, with a percentage of relaxation, at 0.1 mM,of 91, 92, 85, 69 and 7 4 %, respectively. Theophylline shows a correspondent value of 77% (E- max= 100% at 1 mM). (C) 1998 Elsevier Science Ltd. All rights reserved .