SYNTHESIS OF A POTENT WIDE-SPECTRUM SEROTONIN-REUPTAKE, NOREPINEPHRINE-REUPTAKE, DOPAMINE-REUPTAKE INHIBITOR (SNDRI) AND A SPECIES-SELECTIVE DOPAMINE-REUPTAKE INHIBITOR BASED ON THE GAMMA-AMINO ALCOHOL FUNCTIONAL-GROUP

Authors
CARLIER PR LO MMC LO PCK RICHELSON E TATSUMI M REYNOLDS IJ SHARMA TA
Citation
Pr. Carlier et al., SYNTHESIS OF A POTENT WIDE-SPECTRUM SEROTONIN-REUPTAKE, NOREPINEPHRINE-REUPTAKE, DOPAMINE-REUPTAKE INHIBITOR (SNDRI) AND A SPECIES-SELECTIVE DOPAMINE-REUPTAKE INHIBITOR BASED ON THE GAMMA-AMINO ALCOHOL FUNCTIONAL-GROUP, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 487-492
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
487 - 492
Database
ISI
SICI code
0960-894X(1998)8:5<487:SOAPWS>2.0.ZU;2-O
Abstract
A series of gamma-amino alcohols were synthesized and screened for reu ptake inhibition and noncompetitive NMDA antagonism. Compound (+/-)-3f simultaneously and potently inhibits reuptake of 5-HT, NE, and DA, re presenting a potential wide-spectrum reuptake inhibitor antidepressant . In addition, comparative rat and human studies uncovered a species-s elective DA reuptake inhibitor (+/-)-2e, K-D(kDAT)/K-D(rDAT) = 97. (C) 1998 Elsevier Science Ltd. All rights reserved.