RECOGNITION OF 2'-DEOXYISOGUANOSINE TRIPHOSPHATE BY HIV-1 REVERSE-TRANSCRIPTASE AND MAMMALIAN CELLULAR DNA-POLYMERASES

Authors
LUTZ MJ HORLACHER J BENNER SA
Citation
Mj. Lutz et al., RECOGNITION OF 2'-DEOXYISOGUANOSINE TRIPHOSPHATE BY HIV-1 REVERSE-TRANSCRIPTASE AND MAMMALIAN CELLULAR DNA-POLYMERASES, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 499-504
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
499 - 504
Database
ISI
SICI code
0960-894X(1998)8:5<499:RO2TBH>2.0.ZU;2-X
Abstract
HIV-1 reverse transcriptase (RT) incorporates 2'-deoxyisoguanosine tri phosphate (d-isoGTP) opposite thymidine (T) in a DNA template and oppo site uracil (U) in an RNA template about 10 times more efficiently tha n the eukaryotic DNA polymerase a, both in the absence and presence of dATP. (C) 1998 Elsevier Science Ltd. All rights reserved.