PHOSPHODIESTERASE INHIBITORY PROPERTIES OF LOSARTAN - DESIGN AND SYNTHESIS OF NEW LEAD COMPOUNDS

Authors
SEGARRA V CRESPO MI PUJOL F BELETA J DOMENECH T MIRALPEIX M PALACIOS JM CASTRO A MARTINEZ A
Citation
V. Segarra et al., PHOSPHODIESTERASE INHIBITORY PROPERTIES OF LOSARTAN - DESIGN AND SYNTHESIS OF NEW LEAD COMPOUNDS, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 505-510
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
505 - 510
Database
ISI
SICI code
0960-894X(1998)8:5<505:PIPOL->2.0.ZU;2-8
Abstract
A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic a reas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developping PDE 4 inhibitors. New families of c ompounds derived from losartan has been synthesized and their PDE inhi bition has been measured. (C) 1998 Elsevier Science Ltd. All rights re served.