DISCOVERY OF A NEW CYCLOOXYGENASE-2 LEAD COMPOUND THROUGH 3-D DATABASE SEARCHING AND COMBINATORIAL CHEMISTRY

Authors
STEWART KD LOREN S FREY L OTIS E KLINGHOFER V HULKOWER KI
Citation
Kd. Stewart et al., DISCOVERY OF A NEW CYCLOOXYGENASE-2 LEAD COMPOUND THROUGH 3-D DATABASE SEARCHING AND COMBINATORIAL CHEMISTRY, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 529-534
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
529 - 534
Database
ISI
SICI code
0960-894X(1998)8:5<529:DOANCL>2.0.ZU;2-R
Abstract
Using a combination of computational and combinatorial chemistry metho dologies, a phenothiazine compound was discovered that is a selective inhibitor of cyclooxygenase-2 and serves as a lead compound for a pote ntially novel series of anti-inflammatory compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.