USE OF THE 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AND ISOTHIAZOLIDIN-3-ONE 1,1-DIOXIDE SCAFFOLDS IN THE DESIGN OF POTENT INHIBITORS OF SERINE PROTEINASES

Authors
KUANG RZ VENKATARAMAN R RUAN SM GROUTAS WC
Citation
Rz. Kuang et al., USE OF THE 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AND ISOTHIAZOLIDIN-3-ONE 1,1-DIOXIDE SCAFFOLDS IN THE DESIGN OF POTENT INHIBITORS OF SERINE PROTEINASES, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 539-544
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
5
Year of publication
1998
Pages
539 - 544
Database
ISI
SICI code
0960-894X(1998)8:5<539:UOT11A>2.0.ZU;2-O
Abstract
The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidi n-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leuk ocyte elastase (HLE). (C) 1998 Elsevier Science Ltd. All rights reserv ed.