USE OF THE 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AND ISOTHIAZOLIDIN-3-ONE 1,1-DIOXIDE SCAFFOLDS IN THE DESIGN OF POTENT INHIBITORS OF SERINE PROTEINASES
Rz. Kuang et al., USE OF THE 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE AND ISOTHIAZOLIDIN-3-ONE 1,1-DIOXIDE SCAFFOLDS IN THE DESIGN OF POTENT INHIBITORS OF SERINE PROTEINASES, Bioorganic & medicinal chemistry letters, 8(5), 1998, pp. 539-544
The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidi
n-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was
found to yield highly potent, time-dependent inhibitors of human leuk
ocyte elastase (HLE). (C) 1998 Elsevier Science Ltd. All rights reserv
ed.