ADAPTATION OF CORTICAL NMDA RECEPTORS BY CHRONIC TREATMENT WITH SPECIFIC SEROTONIN REUPTAKE INHIBITORS

Glycine displaces [H-3]CGP-39653 3]D,L-(E)-2-amino-4-propyl-5-phosphon o-3-pentenoic acid) binding to the glutamate recognition site with bot h high and low affinity. We reported previously that chronic treatment with antidepressants reduced the proportion of high to low affinity s ites, or, even eliminated the high affinity sites in case of citalopra m. Here, we compared the effects of citalopram with another serotonin specific reuptake inhibitor, fluoxetine on this measure. Chronic admin istration of citalopram or fluoxetine eliminated high affinity glycine -displaceable [H-3]CGP-39653 binding to the mouse cortex in 78 and 56% of animals, respectively, indicating that selective serotonin reuptak e inhibitors produce qualitatively similar adaptive changes at NMDA re ceptors, that differ from other antidepressants in this neurochemical measure. (C) 1998 Elsevier Science B.V.