INHIBITION OF ORNITHINE DECARBOXYLASE BY IFENPRODIL

Authors
BADOLO L DUBOIS J HELSONCAMBIER M HANOCQ M
Citation
L. Badolo et al., INHIBITION OF ORNITHINE DECARBOXYLASE BY IFENPRODIL, European journal of pharmacology, 342(2-3), 1998, pp. 1-2
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
342
Issue
2-3
Year of publication
1998
Pages
1 - 2
Database
ISI
SICI code
0014-2999(1998)342:2-3<1:IOODBI>2.0.ZU;2-6
Abstract
Ifenprodil (NMDA receptor antagonist) was tested as an inhibitor of or nithine decarboxylase. It was found that ifenprodil inhibited ornithin e decarboxylase activity with the same potency as alpha-difluoromethyl ornithine, a major inhibitor of ornithine decarboxylase. This result s uggests that ifenprodil could target either the polyamine site on the NMDA receptor complex or/and polyamine biosynthesis. (C) 1998 Elsevier Science B.V.