A diabetic patient who underwent a triple procedure (penetrating kerat
oplasty, cataract extraction and posterior chamber intraocular lens im
plantation), developed endophthalmitis caused by Proteus mirabilis. Th
e source of infection was the infected donor cornea, which was importe
d from Sri Lanka. The organism was resistant to gentamicin, which was
the only antibiotic present in the storage medium. On top of an aggres
sive antibiotic treatment regime (topical, systemic and intravitreal),
exchange of the infected with a fresh corneal graft and pars plana vi
trectomy were performed. The patient had a speedy recovery and the vis
ual outcome was 20/40 two and a half years after the incident. To our
knowledge, post-keratoplasty endophthalmitis caused by P. mirabilis ha
s never been reported in the literature. We report herein such a case
with good visual outcome. Newer storage medium, such as Optisol GS, mi
ght have a role in preventing keratoplasty-related infection.