STRUCTURAL AND CONFORMATIONAL STUDIES ON 3,3'-BIS[1,3-THIAZOLIDIN-4-ONE] DERIVATIVES WITH BIOLOGICAL-ACTIVITY

thanediyl)bis[2-substituted-1,3-thiazolidin-4-one] derivatives display different biological activities depending on the configuration of the 2,2' centers and on the substitution at C2, C2'. In this context, s[2 -(2'-(5'-methyl)thienyl)-1,3-thiazolidin-4-one] (6b) and hanediyl)bis[ 2-(3'-pyridyl)-1,3-thiazolidin-4-one] (8b) have been prepared. Their s tructural and conformational features, which can be related to the bio logical activity, have been investigated by X-ray diffraction and mole cular modeling techniques. (C) 1998 Elsevier Science B.V.