CENTRAL DOPAMINERGIC D1 AGONISTS IN THE T REATMENT OF PARKINSONS-DISEASE

Authors
SOUBROUILLARD C LOMBARDO C RASCOL O BRUGUEROLLE B BLIN O
Citation
C. Soubrouillard et al., CENTRAL DOPAMINERGIC D1 AGONISTS IN THE T REATMENT OF PARKINSONS-DISEASE, Therapie, 52(6), 1997, pp. 527-534
Citations number
57
Journal title
Therapie → ACNP
ISSN journal
00405957
Volume
52
Issue
6
Year of publication
1997
Pages
527 - 534
Database
ISI
SICI code
0040-5957(1997)52:6<527:CDDAIT>2.0.ZU;2-D
Abstract
Many theories about dopaminergic function in Parkinson's disease are b ased upon the effects of the D2 receptor. Standard treatments mostly i nvolve dopaminergic D2 agonists. However, the recent development of do paminergic D1 agonists should help to clarify the role of the D1 recep tor in the treatment of Parkinson's disease. The authors review the ph ysiopathological, behavioural and therapeutic data on D1 agonists admi nistered in animal models and in patients.