Prenatal diagnosis of craniomaxillofacial malformations permits early
surgery, before 6 months of life and possibly, in the near future, in
utero, thereby obtaining the best aesthetic and functional results. In
creased knowledge of embryology has largely improved the diagnosis of
craniomaxillofacial anomalies, their classification, and therapeutic p
rotocols. We analyzed nine pregnancies (one twin) in which cleft lip a
nd palate (CLP)-isolated or associated with, for example, holoprosence
phaly, hypertelorism, and micrognathia-was diagnosed by ultrasonograph
y. Only one fetus of these pregnancies was later operated on in our un
it. This patient, with 7 years follow-up, represents our clinical case
. For these cases, early diagnosis of CLP allowed informed parental ch
oice regarding the continuation or termination of the affected pregnan
cy and planning of surgical procedures to correct the malformation. Th
is is demonstrated by the presented clinical case involving an infant
operated on within 6 months with success.