ANTIGEN-INDUCED CHANGES IN NEUTROPHIL GRA NULOCYTES SYSTEM FUNCTIONING IN EXPERIMENTS IN-VIVO

Functional activity of neutrophil granulocytes (NG) was studied 1, 24 and 96 hours alter a single immunization of laboratory mice with polyv alent antigen - sheep red cells (SRC). It is shown that SRC immunizati on induces significant changes in the NG system, primarily of a depres sive nature. The most pronounced depression of the number of circulati ng NG and their main functions (receptor, phagocytic, microbicidal sys tems) occurred 1 hour after SRC introduction as well as at the peak of IgM-antibody genesis (the 5th day). Thus, mice immunized with this an tigen, may serve the model of NG system experimental immunodepression.