CLINICOIMMUNOLOGICAL CHARACTERISTICS OF N EUTROPENIA COURSE IN CHILDREN TREATED BY INTERFERON PREPARATIONS

An immunological investigation was made of 29 patients with various fo rms of neutropenia and 19 children with neutropenia syndrome resultant from intrauterine viral-bacterial infection. No relationship was foun d between the immunological indices and neutropenia form or neutrophil count in the peripheral blood. Symptoms of immune deficiency manifest ed in patients with neutropenia syndrome and patients with immune form s of neutropenia in active viral infection and pyoinflammatory disease s. The immunological indices were related to the severity of the disea se clinical symptoms and pathogenicity of the bacterial flora. The stu dy of the interferon status discovered deficiency of alfa and gamma in terferon in the blood of the above patients. 23 patients received inte rferon preparations which promoted rehabilitation of the immune system , recovery of the interferon status, elimination of the viruses, clean sing of bacterial infection foci. Neotrophil count in the peripheral b lood increased, proliferation and maturation of neutrophils in the bon e marrow enhanced. Interferon and leukinferon may be recommended for u se in patients with neutropenia to ensure bactericidal activity of pha gocytes, antiviral defense, prevention of bacterial complications.