RADICAL POLYADDITIONS OF DITHIOLS WITH DIOLEFINS DERIVED FROM OPTICALLY-ACTIVE AMINO-ALCOHOLS

Syntheses of poly(ester-amide-sulfide)s by radical polyadditions of di olefins with dithiols and oxidations and enzymatic degradation of the obtained polymers were examined. The diolefins were synthesized from o ptically active amino alcohols and 4-pentenoic acid. The radical polya dditions of the diolefins with dithiols were carried out in the presen ce of AIBN (3 mol %) in DMF to afford high molecular weight polymers. The sulfide group in the polymer was selectively oxidized to sulfoxide and sulfone groups according to the amount of H2O2 used. The poly(est er-amide-sulfide)s derived from alaninol were degraded by lipase Rhizo pus arrhizus.