NEW TRIQUINANE-TYPE SESQUITERPENOIDS FROM MACROCYSTIDIA-CUCUMIS (BASIDIOMYCETES)

Arthrosporone (1) and eight new triquinane-type sesquiterpenoids have been isolated from mycelial cultures of the agaric Macrecystidia cucum is. The cucumins A-D (2, 4-6) are highly unsaturated hirsutane derivat ives, whereas the cucumins E-G (7-9) represent a new type of linear tr iquinanes. Cucumin H (10) is a new member of the ceratopicane group. T he absolute configuration of cucumin F (8) was assigned by H-1-NMR ana lysis of the corresponding Mosher esters. Two further metabolites were identified as cycle(phenylalanylprolyl) (12) and cyclo(leucylprolyl) (13). Cucumin A (2) exhibits antibacterial and cytotoxic activities.