INHIBITION OF SHEAR-INDUCED PLATELET-AGGREGATION BY CHINESE HERBAL MEDICINES

Authors
LIAO FL LI B
Citation
Fl. Liao et B. Li, INHIBITION OF SHEAR-INDUCED PLATELET-AGGREGATION BY CHINESE HERBAL MEDICINES, Clinical hemorheology and microcirculation, 17(4), 1997, pp. 315-318
Citations number
5
Categorie Soggetti
Hematology,"Peripheal Vascular Diseas
Journal title
Clinical hemorheology and microcirculation → ACNP
ISSN journal
13860291
Volume
17
Issue
4
Year of publication
1997
Pages
315 - 318
Database
ISI
SICI code
1386-0291(1997)17:4<315:IOSPBC>2.0.ZU;2-9
Abstract
Shear-induced platelet aggregation (SIPA) plays an important role in v ascular diseases. In this study, SIPA was generated by a computerized cone-plate apparatus. Six compounds from Chinese herbal medicine were selected for in vitro and in vivo tests. Rabbit and rat were involved in the tests accordingly. Ligustrazine hydrochloridi appeared to be mo st effective for inhibition of SIPA. The inhibition rate of SIPA reach ed 44.2% (p < 0.01) for an in vitro concentration of 1 mg/ml, and 46.1 % (p < 0.01) for an in vivo dose of 50 mg/kg.