CHARACTERISTICS OF BENZODIAZEPINE RECEPTO RS IN RAT CEREBELLUM AFTER DEVELOPMENT OF KORAZOL SEIZURES AND KINDLING

The acute korazol (pentylenetetrazol) injection (50 mg/kg) induced sei zures which were accompanied by a long-lasting (from 30 minutes to 3 d ays) decrease in benzodiazepine receptor (BDR) density (B-max) in rat cerebellum without change in affinity. The density of the BDR was norm alized on the 7th day after seizure termination. There were no differe nces in the initial BDR characteristics between the animals more sensi tive to korazol ia dose of 25 m/kg was sufficient for seizure inductio n) and less sensitive (30 mg/kg were ineffective). The chronical daily (for 24 days) administration of korazol in a subconvulsive dose led t o an increase in seizure readiness (kindling), In 30 min after the las t korazol injection the BDR density was decreased to the same extent a s after the acute 50 mg/kg korasol administratio. The BDR density was normalized on the 7th day after kindling, It was demonstrated that the high-dose-induced and after-kindling seizures were underlied by the s ame mechanins. The results suggest that the development of kindling de pends on the state of the long-lasting receptors rather than the devel opment of kindling forms the long-lasting reactions, The process of su mmation is-at the basis of kindling development. The long-lasting decr ease in activity of BDR receptors induced by a subconvulsive dose of k orazol is summed with the following effect of the same dose.