THE STUDY OF ANXIOLYTIC ACTIVITY OF TUFTS IN ANALOG IN INBRED MICE WITH DIFFERENT TYPES OF EMOTIONAL-STRESS REACTION

The anxiolytic efect of the synthetic analogue of the endogenous pepti de tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) was studied in inbred mice Ba lb/c (C) and C57Bl/6 (B6) with different heritable types of emotional- stress reaction, In C strain with genetically high level of anxiety an d ''passive'' type of behaviour under conditions of avoidable and unav oidable stress (open field, elevated plus-maze, light-dark chamber) th e heptapeptide prevented manifestations of anxiety being administered intraperitoneally in a wide range of active doses (200-3000 mcg/kg), T he drug did not change the behaviour of B6 mice with low level of anxi ety and active type of emotional-stress reaction, The described effect is comparable with tranquillizing-activatory action of low doses of b enzodiazepine tranquillizers, however, in contrast to the latter, the heptapeptide has no side inhibitory behavioural effects even in high d oses, The heptapeptide may be considered as a promising new anxioselec tive drug without side inhibitoty behavioural effects which are typica l for benzodiazepine tranquillizers.