RISK-FACTORS FOR GLIOMA IN ADULTS - A CASE-CONTROL STUDY IN NORTHEASTCHINA

A case-control study of risk factors for glioma in adults was carried out in Heilongjiang province in northeast China Between September 1989 and May 1995, 218 histologically confirmed cases of glioma requiring surgery for tumor removal (139 astrocytoma glioma and 79 other glioma) and 436 controls with non-neoplastic and non-neurological disease wer e recruited and personally interviewed in the wards of six major hospi tals, Controls were matched by sex, age, and area of residence. Occupa tional, lifestyle, and medical information was obtained through a stan dardized questionnaire. Use of liquor was associated with cancer risk. Compared with males who never drank Liquor, males with total lifetime liquor consumption of less than 1000 liters had an adjusted odds rati o (OR) of 1.60 (95% CI: 0.89-2.88) and for more than 1000 liters, 2.73 (95% CI: 1.06-7.08). Statistically significant associations were also found for diseases related to the brain (OR: 5.75; 95% CI: 1.08-30.47 ) and trauma to the head requiring medical attention (OR: 4.09; 95% CI : 2.51-10.31). Increased consumption of vegetables and of fruit were e ach associated with decreased,glioma risk. Compared with lowest quarti le intake, adjusted risks associated ts with highest quartile intake w ere 0.51 (95% CI: 0.29-0.89) for total vegetables and 0.28 (95% CI: 0. 16-0.51) for total fruit.