The interface effects arising in the measurement of absorbed dose by i
onization chambers, owing to the inhomogeneity between the walls and t
he gas, have been evaluated by an analytical model. The geometrical si
tuation considered here is appropriate for representing the behaviour
of a plane-parallel ionization chamber exposed to a radiotherapeutic b
eam of protons. Two gases, dry air and tissue equivalent gas (methane
based), as well as six materials commonly used in ionization chamber w
alls, i.e. graphite, A-150 tissue equivalent plastic, C-522 air equiva
lent plastic, nylon type 6, polymethyl methacrylate and polystyrene, h
ave been examined. The analysis of the results shows that, within the
limits of the detector dimensions and proton energies commonly used in
the dosimetry of radiotherapeutic beams, these effects, if not taken
into account in the measurement interpretation, can entail deviations
of up to about 2% with respect to the correct absorbed dose in gas.