SYNTHESIS AND STUDIES OF ORGANIC NITRATES OF THE HETEROFUNCTIONAL SERIES - 1 - SYNTHESIS AND STRUCTURE OF N-NICOTINOYLTRIS(HYDROXYMETHYL)AMINOMETHANE TRINITRATE HYDRONITRATE
Am. Korolev et al., SYNTHESIS AND STUDIES OF ORGANIC NITRATES OF THE HETEROFUNCTIONAL SERIES - 1 - SYNTHESIS AND STRUCTURE OF N-NICOTINOYLTRIS(HYDROXYMETHYL)AMINOMETHANE TRINITRATE HYDRONITRATE, Russian chemical bulletin, 46(12), 1997, pp. 2110-2112
N-Nicotinoyltris(hydroxymethyl)aminomethane trinitrate hydronitrate, a
n analog of N-nicotinoylethanolamine nitrate (the active principle of
the antianginal drug nicorandil), was prepared by O-nitration of the c
orresponding triol with concentrated HNO3. The structure of the reacti
on product was established by X-ray structural analysis.