EFFECT OF SODIUM ACID PHOSPHATE AND INOSINE ON THE COURSE OF DICTYOCAULUS-FILARIA INFECTION IN SHEEP

A comparative study on effect of sodium acid phosphate (SAP) and inosi ne (IVO2 releasers) was carried out in Dictyocaulus filaria infected m ale Dorset-Muzaffarnagari lambs, aged 8-12 weeks. During patency, SAP and inosine were intravenously administered daily @ 1000 mg/animal, fr om day-30 post-infection outwards. The comparative effect of these dru gs on the course of infection was assessed weekly by monitoring altera tions in haematobiochemical parameters and faecal larval output. Anima ls treated with SAP alone or in combination with inosine had significa ntly higher estimated faecal larval output (58.3 and 56.3 million/anim al) during useful patency in comparison with animals receiving inosine (36.2 million/animal) and/or untreated control (24.1 million/animal). Besides, the animals treated with SAP continued to be in useful paten cy even at the end of the experiment. In these animals, the post-treat ment haematobiochemical values of various parameters restored to near- normal leaves in comparison with infected-untreated controls and/or in osine-treated animals. Clinically, these animals had better health sta tus and higher survival rate.