NEPHROCALCINOSIS IN 3 SIBLINGS WITH IDIOPATHIC HYPERCALCIURIA

Idiopathic hypercalciuria (IH) associated with nephrocalcinosis was fo und in three of six siblings. After the three affected children were m aintained on a low-calcium diet, they demonstrated increasing hypercal ciuria, parathyroid hormone, and vitamin D-3 levels. An oral calcium l oading test was not necessary to diagnose renal IH. During treatment w ith hydrochlorothiazide, the calcium excretion was normalized. These p atients are remarkable because nephrocalcinosis is generally regarded as a rare complication of renal M. Moreover, the fact that three of si x siblings are affected raises the question of whether the renal form of IH is genetically distinct from other forms of IH.