IN-VITRO GENOTOXICITY OF POLYCYCLIC MUSK FRAGRANCES IN THE MICRONUCLEUS TEST

The synthetic polycyclic musk fragrance compounds galaxolide 6,6,7,8,8 -hexamethylcyclopenta-(g)-2-benzopyrane), tonalide (7-acetyl-1,1,3,4,4 ,6-hexamerthyltetraline), celestolide (4-acetyl-1,1-dimethyl-6-tertbut ylindane), phantolide (6-acetyl-1,1,2,3,3,5-hexamethylindane), cashmer an (6,7-dihydro-1,1,2,3,3-pentamethyl-4-(5H) indanone) and traseolide (5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane) were examined for the ir genotoxicity in the micronucleus test (MNT) with human lymphocytes in vitro in the presence and absence of an exogenous metabolizing syst em containing rat liver S9 and the metabolically competent human hepat oma cell line Hep G2. Compound concentrations were employed up to cyto toxic doses. Galaxolide, tonalide, celestolide, phantolide, cashmeran and traseolide revealed no genotoxicity in the micronucleus test with human lymphocytes and with the human hepatoma cell line Hep G2. (C) 19 97 Elsevier Science B.V.