CISPLATIN NEUROTOXICITY PRESENTING AS REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME

Visual disturbance, hypertension, convulsions, and unconsciousness dev eloped in a 70-year-old man after cisplatin chemotherapy and upper-lim b amputation for osteosarcoma. MR imaging revealed bilateral reversibl e ab normalities in the occipital, parietal, and frontal white matter, Clinical and neuroradiologic features corresponded to reversible post erior leukoencephalopathy syndrome (RPLS), which some immunosuppressiv e and chemotherapeutic drugs have been reported to trigger. Cisplatin may be among these drugs, Our patient also had hypomagnesemia, which m ay have figured in the pathophysiology.