ACQUIRED HEPATOCEREBRAL DEGENERATION - MR AND PATHOLOGICAL FINDINGS

Acquired (non-Wilsonian) hepatocerebral degeneration (AHD) is a rare i rreversible neurologic syndrome that occurs in patients with chronic l iver disease associated with multiple metabolic insults. The pathophys iology and the locations of the cerebral injuries are incompletely und erstood. We describe a patient with fatal hepatic cirrhosis and AHD in whom MR images showed abnormalities in the brachium pontis bilaterall y. Neuropathologic evaluation disclosed multiple regions of subcortica l spongiform white matter changes.