IMPAIRED ORIENTATION IN ACUTE STROKE - FREQUENCY, DETERMINANTS, AND TIME-COURSE OF RECOVERY - THE COPENHAGEN STROKE STUDY

Orientation is an indicator of general intellectual function and is de fined as the ability to report time, place, and personal data. Our kno wledge of orientation in acute stroke is sparse. We examined the frequ ency of impaired orientation ill acute stroke, its determinants, and r ecovery in 653 consecutive patients with acute stroke who were not unc onscious and who were without severe aphasia. Prospective assessments of orientation and stroke severity were done by the Scandinavian Neuro logic Stroke Scale at the time of acute admission and hereafter weekly until the end of rehabilitation. Impaired orientation was found in 23 % of the patients on acute admission and in 12% of the survivors after completed rehabilitation. A stationary level of orientation was achie ved by 80% of the patients within 2 weeks and by 95% within 6 weeks, A multiple linear regression analysis found neurological score (B = 0.0 27, SE(B) = 0.003), age (B = -0.013, SE(B)= 0.003), and comorbidity (B = -0.023, SE(B)= 0.078), but not sex, prior stroke, handedness, or si de of stroke lesion to be significant independent determinants of orie ntation score on acute admission. Lesions involving the anterior and m edial thalamus and/or any of the cerebral lobes were associated with i mpaired orientation. In conclusion, impaired orientation is frequent i n acute stroke and the time-course of recovery is similar to what has been found in other neuropsychological impairments with the major part of recovery early after stroke onset.