MACROMOLECULAR STRUCTURE AND REACTIVITY - PEPTIDE-SYNTHESIS USING POLYMERIC ACYL TRANSFER REAGENTS

The use of polystyrene-and polyacrolein-supported oximinoesters and ox iminodithiocarbonic anhydrides in the synthesis of some peptides is il lustrated. The efficiency of the peptide synthesis revealed a signific ant influence of the nature of the support, nature of crosslinking age nt and extent of crosslinking. An increase in the polarity and hydroph ilicity of the macromolecular support invariably resulted in an increa se in the yield of the peptide. Thus, tetraethyleneglycol diacrylate c rosslinked polyacrolein support was found to be more efficient in effe cting peptide synthesis than other polystyrene-based supports and divi nylbenzene crosslinked polyacrolein support. (C) 1998 SCI.