STRUCTURE-ACTIVITY-RELATIONSHIPS OF IMPERIALINE DERIVATIVES AND THEIRANTICHOLINERGIC ACTIVITY

Authors
ATTAURRAHMAN,"CHOUDHARY MI FAROOQ A ANJUM S BAUMGOLD J SENER B
Citation
Mi. Attaurrahman,"choudhary et al., STRUCTURE-ACTIVITY-RELATIONSHIPS OF IMPERIALINE DERIVATIVES AND THEIRANTICHOLINERGIC ACTIVITY, Planta medica, 64(2), 1998, pp. 172-174
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
64
Issue
2
Year of publication
1998
Pages
172 - 174
Database
ISI
SICI code
0032-0943(1998)64:2<172:SOIDAT>2.0.ZU;2-2
Abstract
In order to check the structure-activity relationship and prepare more potent derivatives of imperialine with anticholinergic activity, impe rialinol (2), 3 beta-acetoxyimperialine (3), 3 beta-propionoxyimperial ine (4), and 3 beta-butyroxyimperialine (5) were prepared. Compounds 4 and 5 displayed better anticholinergic activity against muscarinic re ceptors of the heart and brain than imperialine (1). The decrease in a ctivity in 2 showed the importance of the 6-keto functionality in impa rting the anticholinergic activity.